Synthesis, Properties, and Derivatization of Poly(dihydrogermane): A Germanium-Based Polyethylene Analogue
Polygermanes are germanium-based analogues of polyolefins and possess polymer backbones made up catenated Ge atoms. In the present contribution we report the preparation of a germanium polyethylene analogue, polydihydrogermane (GeH2)n, via two straightforward approaches that involve topotactic deintercalation of Ca ions from the CaGe Zintl phase.
The resulting (GeH2)n possesses morphologically dependent chemical and electronic properties and thermally decomposes to yield amorphous hydrogenated Ge. We also show that the resulting (GeH2)n provides a platform from which functionalized polygermanes can be prepared via thermally induced hydrogermylation-mediated pendant group substitution.
composite-agency
 PEG Antibody / Polyethylene Glycol |
|
R20194BTN-50UG |
NSJ Bioreagents |
50ug |
EUR 489 |
 CLIA Kit) Polyethylene Glycol (PEG) CLIA Kit |
|
20-abx490560 |
Abbexa |
-
EUR 11090.40
-
EUR 5904.00
-
EUR 1356.00
|
- 10 × 96 tests
- 5 × 96 tests
- 96 tests
|
|
|
 ELISA Kit) General Polyethylene Glycol (PEG) ELISA Kit |
|
CEX163Ge-10x96wellstestplate |
Cloud-Clone |
10x96-wells test plate |
EUR 7248.6 |
|
|
|
Description: This is Competitive Enzyme-linked immunosorbent assay for detection of General Polyethylene Glycol (PEG) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids. |
General Polyethylene Glycol (PEG) ELISA Kit |
|
CEX163Ge-1x48wellstestplate |
Cloud-Clone |
1x48-wells test plate |
EUR 702.12 |
|
|
|
Description: This is Competitive Enzyme-linked immunosorbent assay for detection of General Polyethylene Glycol (PEG) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids. |
General Polyethylene Glycol (PEG) ELISA Kit |
|
CEX163Ge-1x96wellstestplate |
Cloud-Clone |
1x96-wells test plate |
EUR 951.6 |
|
|
|
Description: This is Competitive Enzyme-linked immunosorbent assay for detection of General Polyethylene Glycol (PEG) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids. |
General Polyethylene Glycol (PEG) ELISA Kit |
|
CEX163Ge-5x96wellstestplate |
Cloud-Clone |
5x96-wells test plate |
EUR 3922.2 |
|
|
|
Description: This is Competitive Enzyme-linked immunosorbent assay for detection of General Polyethylene Glycol (PEG) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids. |
General Polyethylene Glycol (PEG) ELISA Kit |
|
4-CEX163Ge |
Cloud-Clone |
-
EUR 7309.20
-
EUR 3862.80
-
EUR 952.80
|
- 10 plates of 96 wells
- 5 plates of 96 wells
- 1 plate of 96 wells
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|
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Description: Enzyme-linked immunosorbent assay based on the Competitive Inhibition method for detection of General Polyethylene Glycol (PEG) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids with no significant corss-reactivity with analogues from other species. |
) General Polyethylene Glycol ELISA Kit (PEG) |
|
RK00701 |
Abclonal |
96 Tests |
EUR 687.6 |
 Antibody (Biotin)) Polyethylene Glycol (PEG) Antibody (Biotin) |
|
abx021052-005mg |
Abbexa |
0.05 mg |
EUR 978 |
|
|
 Protein (BSA)) Polyethylene Glycol (PEG) Protein (BSA) |
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20-abx651925 |
Abbexa |
-
EUR 693.60
-
EUR 309.60
-
EUR 2064.00
-
EUR 828.00
-
EUR 510.00
|
- 100 ug
- 10 ug
- 1 mg
- 200 ug
- 50 ug
|
|
|
 Protein (OVA)) Polyethylene Glycol (PEG) Protein (OVA) |
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20-abx651926 |
Abbexa |
-
EUR 693.60
-
EUR 309.60
-
EUR 2064.00
-
EUR 828.00
-
EUR 510.00
|
- 100 ug
- 10 ug
- 1 mg
- 200 ug
- 50 ug
|
|
|
) BSA Conjugated Polyethylene Glycol (PEG) |
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4-CPX163Ge11 |
Cloud-Clone |
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EUR 496.32
-
EUR 256.80
-
EUR 1531.20
-
EUR 590.40
-
EUR 1060.80
-
EUR 408.00
-
EUR 3648.00
|
- 100 ug
- 10ug
- 1 mg
- 200 ug
- 500 ug
- 50ug
- 5 mg
|
|
|
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Description: Recombinant Pan-species Polyethylene Glycol expressed in: E.coli |
) OVA Conjugated Polyethylene Glycol (PEG) |
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4-CPX163Ge21 |
Cloud-Clone |
-
EUR 496.32
-
EUR 256.80
-
EUR 1531.20
-
EUR 590.40
-
EUR 1060.80
-
EUR 408.00
-
EUR 3648.00
|
- 100 ug
- 10ug
- 1 mg
- 200 ug
- 500 ug
- 50ug
- 5 mg
|
|
|
|
Description: Recombinant Pan-species Polyethylene Glycol expressed in: E.coli |
) ELISA kit for General PEG (Polyethylene Glycol) |
|
ELK8264 |
ELK Biotech |
1 plate of 96 wells |
EUR 446.4 |
|
|
|
Description: A competitive Inhibition ELISA kit for detection of Polyethylene Glycol from General in samples from blood, serum, plasma, cell culture fluid and other biological fluids. |
 Polyclonal Antibody (Pan-species)) Polyethylene Glycol (PEG) Polyclonal Antibody (Pan-species) |
|
4-PAX163Ge01 |
Cloud-Clone |
-
EUR 303.60
-
EUR 3138.00
-
EUR 778.80
-
EUR 382.80
-
EUR 260.40
|
- 100ul
- 10ml
- 1ml
- 200ul
- 20ul
|
|
|
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Description: A Rabbit polyclonal antibody against Pan-species Polyethylene Glycol (PEG) |
 Polyclonal Antibody (Pan-species), APC) Polyethylene Glycol (PEG) Polyclonal Antibody (Pan-species), APC |
|
4-PAX163Ge01-APC |
Cloud-Clone |
-
EUR 426.00
-
EUR 4102.80
-
EUR 1137.60
-
EUR 544.80
-
EUR 268.80
|
- 100ul
- 10ml
- 1ml
- 200ul
- 20ul
|
|
|
|
Description: A Rabbit polyclonal antibody against Pan-species Polyethylene Glycol (PEG). This antibody is labeled with APC. |
 Polyclonal Antibody (Pan-species), Biotinylated) Polyethylene Glycol (PEG) Polyclonal Antibody (Pan-species), Biotinylated |
|
4-PAX163Ge01-Biotin |
Cloud-Clone |
-
EUR 381.60
-
EUR 3078.00
-
EUR 903.60
-
EUR 469.20
-
EUR 266.40
|
- 100ul
- 10ml
- 1ml
- 200ul
- 20ul
|
|
|
|
Description: A Rabbit polyclonal antibody against Pan-species Polyethylene Glycol (PEG). This antibody is labeled with Biotin. |
 Polyclonal Antibody (Pan-species), Cy3) Polyethylene Glycol (PEG) Polyclonal Antibody (Pan-species), Cy3 |
|
4-PAX163Ge01-Cy3 |
Cloud-Clone |
-
EUR 518.40
-
EUR 5420.40
-
EUR 1467.60
-
EUR 676.80
-
EUR 308.40
|
- 100ul
- 10ml
- 1ml
- 200ul
- 20ul
|
|
|
|
Description: A Rabbit polyclonal antibody against Pan-species Polyethylene Glycol (PEG). This antibody is labeled with Cy3. |
 Polyclonal Antibody (Pan-species), FITC) Polyethylene Glycol (PEG) Polyclonal Antibody (Pan-species), FITC |
|
4-PAX163Ge01-FITC |
Cloud-Clone |
-
EUR 364.80
-
EUR 3306.00
-
EUR 933.60
-
EUR 459.60
-
EUR 238.80
|
- 100ul
- 10ml
- 1ml
- 200ul
- 20ul
|
|
|
|
Description: A Rabbit polyclonal antibody against Pan-species Polyethylene Glycol (PEG). This antibody is labeled with FITC. |
 Polyclonal Antibody (Pan-species), HRP) Polyethylene Glycol (PEG) Polyclonal Antibody (Pan-species), HRP |
|
4-PAX163Ge01-HRP |
Cloud-Clone |
-
EUR 388.80
-
EUR 3574.80
-
EUR 1005.60
-
EUR 492.00
-
EUR 252.00
|
- 100ul
- 10ml
- 1ml
- 200ul
- 20ul
|
|
|
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Description: A Rabbit polyclonal antibody against Pan-species Polyethylene Glycol (PEG). This antibody is labeled with HRP. |
 Polyclonal Antibody (Pan-species), PE) Polyethylene Glycol (PEG) Polyclonal Antibody (Pan-species), PE |
|
4-PAX163Ge01-PE |
Cloud-Clone |
-
EUR 364.80
-
EUR 3306.00
-
EUR 933.60
-
EUR 459.60
-
EUR 238.80
|
- 100ul
- 10ml
- 1ml
- 200ul
- 20ul
|
|
|
|
Description: A Rabbit polyclonal antibody against Pan-species Polyethylene Glycol (PEG). This antibody is labeled with PE. |
 Polyclonal Antibody (Pan-species), APC-Cy7) Polyethylene Glycol (PEG) Polyclonal Antibody (Pan-species), APC-Cy7 |
|
4-PAX163Ge01-APC-Cy7 |
Cloud-Clone |
-
EUR 708.00
-
EUR 8061.60
-
EUR 2132.40
-
EUR 945.60
-
EUR 393.60
|
- 100ul
- 10ml
- 1ml
- 200ul
- 20ul
|
|
|
|
Description: A Rabbit polyclonal antibody against Pan-species Polyethylene Glycol (PEG). This antibody is labeled with APC-Cy7. |
 Mouse Anti-PEG mAb [Anti-Polyethylene glycol monoclonal antibody] |
|
57000 |
AAT Bioquest |
50 ug |
EUR 199 |
) HSP70 ELISA Kit (High-Sensitivity) |
|
abx259904-96well |
Abbexa |
96 well |
EUR 1299.6 |
|
|
HSP70 ELISA Kit (High-Sensitivity) |
|
EK7109 |
BosterBio |
96wells/kit, with removable strips. |
EUR 909.6 |
HSP70 ELISA Kit (High-Sensitivity) |
|
SKT-108-480 |
Stressmarq |
5 plates of 96 wells |
EUR 3242.4 |
|
|
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Description: Sandwich ELISA kit used for quantitate HSP70 concentration in Serum, Plasma, Cell Lysates, Tissue samples from Human, Monkey, Dog, Rat, Mouse |
HSP70 ELISA Kit (High-Sensitivity) |
|
SKT-108-96 |
Stressmarq |
1 plate of 96 wells |
EUR 822 |
|
|
|
Description: Sandwich ELISA kit used for quantitate HSP70 concentration in Serum, Plasma, Cell Lysates, Tissue samples from Human, Monkey, Dog, Rat, Mouse |
) OVAL High Sensitivity ELISA Kit (OKCD01353) |
|
OKCD01353 |
Aviva Systems Biology |
96 Wells |
EUR 715.2 |
|
Description: Description of target: Non-inhibitory serpin. Storage protein of egg white.;Species reactivity: pan-species;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: <28 pg/mL |
) Human EGF ELISA Kit (High Sensitivity) |
|
RK00024HS |
Abclonal |
96 Tests |
EUR 704.4 |
 Human Anti-PEG IgG ELISA Kit, 96 tests, Quantitative |
|
PEG-010 |
Alpha Diagnostics |
1 Kit |
EUR 854.4 |
 Human Anti-PEG IgM ELISA Kit, 96 tests, Quantitative |
|
PEG-020 |
Alpha Diagnostics |
1 Kit |
EUR 854.4 |
 Mouse Anti-PEG IgG ELISA Kit, 96 tests, Quantitative |
|
PEG-030 |
Alpha Diagnostics |
1 Kit |
EUR 854.4 |
 Mouse Anti-PEG IgM ELISA Kit, 96 tests, Quantitative |
|
PEG-040 |
Alpha Diagnostics |
1 Kit |
EUR 854.4 |
 Monkey Anti-PEG IgG ELISA Kit, 96 tests, Quantitative |
|
PEG-050 |
Alpha Diagnostics |
1 Kit |
EUR 854.4 |
 Monkey Anti-PEG IgM ELISA Kit, 96 tests, Quantitative |
|
PEG-060 |
Alpha Diagnostics |
1 Kit |
EUR 854.4 |
 Rat Anti-PEG IgG ELISA Kit, 96 tests, Quantitative |
|
PEG-070 |
Alpha Diagnostics |
1 Kit |
EUR 854.4 |
 Rat Anti-PEG IgM ELISA Kit, 96 tests, Quantitative |
|
PEG-080 |
Alpha Diagnostics |
1 Kit |
EUR 854.4 |
 ChromaFlash High-Sensitivity ChIP Kit |
|
P-2027-24 |
EpiGentek |
24 Reactions |
EUR 338.8 |
ChromaFlash High-Sensitivity ChIP Kit |
|
P-2027-48 |
EpiGentek |
48 Reactions |
EUR 512.6 |
ChromaFlash High-Sensitivity ChIP Kit |
|
P-2027 |
EpiGentek |
-
EUR 771.66
-
EUR 338.80
-
EUR 512.60
|
- 48 Reactions
- 24 Reactions
- 48 Reactions
|
 methyl ether (mPEG) Molecular Weight: 20000) Poly(ethylene glycol) methyl ether (mPEG) Molecular Weight: 20000 |
|
PEG-20K |
Alpha Diagnostics |
100 mg |
EUR 270 |
) Morphine antibody (High Sensitivity) |
|
10-1379 |
Fitzgerald |
1 mg |
EUR 202.8 |
|
Description: Mouse monoclonal Morphine antibody |
 ELISA Kit) Rat High Sensitivity Insulin (INS) ELISA Kit |
|
abx363835-96tests |
Abbexa |
96 tests |
EUR 943.2 |
|
|
 High-sensitivity Human Growth Hormone ELISA Kit |
|
DEIA449 |
Creative Diagnostics |
96T |
EUR 814.8 |
|
Description: Thishigh-sensitivity Human Growth Hormone ELISA Kit is to be used for the invitro quantitative determination of human growth hormone (hGH) concentrationsin serum. |
 (OKCD01300)) IGF1 High Sensitivity ELISA Kit (Dog) (OKCD01300) |
|
OKCD01300 |
Aviva Systems Biology |
96 Wells |
EUR 1123.2 |
|
Description: Description of target: The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca2+-dependent exocytosis of IGF1 is required for sensory perception of smell in the olfactory bulb. Acts as a ligand for IGF1R. Binds to the alpha subunit of IGF1R, leading to the activation of the intrinsic tyrosine kinase activity which autophosphorylates tyrosine residues in the beta subunit thus initiatiating a cascade of down-stream signaling events leading to activation of the PI3K-AKT/PKB and the Ras-MAPK pathways. Binds to integrins ITGAV:ITGB3 and ITGA6:ITGB4. Its binding to integrins and subsequent ternary complex formation with integrins and IGFR1 are essential for IGF1 signaling. Induces the phosphorylation and activation of IGFR1, MAPK3/ERK1, MAPK1/ERK2 and AKT1.;Species reactivity: Dog;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 6.5 pg/mL |
 (OKCD01301)) Il10 High Sensitivity ELISA Kit (Mouse) (OKCD01301) |
|
OKCD01301 |
Aviva Systems Biology |
96 Wells |
EUR 1044 |
|
Description: Description of target: Inhibits the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF and GM-CSF produced by activated macrophages and by helper T-cells. ;Species reactivity: Mouse;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 0.43 pg/mL |
 (OKCD01303)) Il1a High Sensitivity ELISA Kit (Mouse) (OKCD01303) |
|
OKCD01303 |
Aviva Systems Biology |
96 Wells |
EUR 1090.8 |
|
Description: Description of target: Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells. ;Species reactivity: Mouse;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 1.03 pg/mL |
 (OKCD01304)) Il1a High Sensitivity ELISA Kit (Rat) (OKCD01304) |
|
OKCD01304 |
Aviva Systems Biology |
96 Wells |
EUR 888 |
|
Description: Description of target: Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells. ;Species reactivity: Rat;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 3.8 pg/mL |
 (OKCD01305)) IL2 High Sensitivity ELISA Kit (Human) (OKCD01305) |
|
OKCD01305 |
Aviva Systems Biology |
96 Wells |
EUR 856.8 |
|
Description: Description of target: Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells. ;Species reactivity: Human;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 0.51 pg/mL |
 (OKCD01306)) IL6 High Sensitivity ELISA Kit (Bovine) (OKCD01306) |
|
OKCD01306 |
Aviva Systems Biology |
96 Wells |
EUR 1123.2 |
|
Description: Description of target: Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation.;Species reactivity: Bovine;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 0.45 pg/mL |
 (OKCD01307)) IL6 High Sensitivity ELISA Kit (Goat) (OKCD01307) |
|
OKCD01307 |
Aviva Systems Biology |
96 Wells |
EUR 1248 |
|
Description: Description of target: Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation.;Species reactivity: Goat;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 0.138 pg/mL |
 (OKCD01308)) IL6 High Sensitivity ELISA Kit (Human) (OKCD01308) |
|
OKCD01308 |
Aviva Systems Biology |
96 Wells |
EUR 777.6 |
|
Description: Description of target: Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation. ;Species reactivity: Human;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 0.35 pg/mL |
 (OKCD01309)) IL6 High Sensitivity ELISA Kit (Sheep) (OKCD01309) |
|
OKCD01309 |
Aviva Systems Biology |
96 Wells |
EUR 1232.4 |
|
Description: Description of target: Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation.;Species reactivity: Sheep;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 0.46 pg/mL |
 (OKCD01310)) Il6 High Sensitivity ELISA Kit (Rat) (OKCD01310) |
|
OKCD01310 |
Aviva Systems Biology |
96 Wells |
EUR 730.8 |
|
Description: Description of target: Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation.;Species reactivity: Rat;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 0.47 pg/mL |
 (OKCD01311)) IL8 High Sensitivity ELISA Kit (Human) (OKCD01311) |
|
OKCD01311 |
Aviva Systems Biology |
96 Wells |
EUR 777.6 |
|
Description: Description of target: IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus. IL-8(6-77) has a 5-10-fold higher activity on neutrophil activation, IL-8(5-77) has increased activity on neutrophil activation and IL-8(7-77) has a higher affinity to receptors CXCR1 and CXCR2 as compared to IL-8(1-77), respectively.;Species reactivity: Human;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 1.7 pg/mL |
 (OKCD01312)) LN High Sensitivity ELISA Kit (Human) (OKCD01312) |
|
OKCD01312 |
Aviva Systems Biology |
96 Wells |
EUR 997.2 |
|
Description: Description of target: ;Species reactivity: Human;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 11.5 pg/mL |
 (OKCD01313)) MMP1 High Sensitivity ELISA Kit (Rabbit) (OKCD01313) |
|
OKCD01313 |
Aviva Systems Biology |
96 Wells |
EUR 1075.2 |
|
Description: Description of target: Cleaves collagens of types I, II, and III at one site in the helical domain. Also cleaves collagens of types VII and X. ;Species reactivity: Rabbit;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 11.5 pg/mL |
 (OKCD01314)) MMP13 High Sensitivity ELISA Kit (Human) (OKCD01314) |
|
OKCD01314 |
Aviva Systems Biology |
96 Wells |
EUR 997.2 |
|
Description: Description of target: Plays a role in the degradation of extracellular matrix proteins including fibrillar collagen, fibronectin, TNC and ACAN. Cleaves triple helical collagens, including type I, type II and type III collagen, but has the highest activity with soluble type II collagen. Can also degrade collagen type IV, type XIV and type X. May also function by activating or degrading key regulatory proteins, such as TGFB1 and CTGF. Plays a role in wound healing, tissue remodeling, cartilage degradation, bone development, bone mineralization and ossification. Required for normal embryonic bone development and ossification. Plays a role in the healing of bone fractures via endochondral ossification. Plays a role in wound healing, probably by a mechanism that involves proteolytic activation of TGFB1 and degradation of CTGF. Plays a role in keratinocyte migration during wound healing. May play a role in cell migration and in tumor cell invasion.1;Species reactivity: Human;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 12.1 pg/mL |
Coarse grained simulation of the aggregation and structure control of polyethylene nanocrystals
Polyethylene (PE) telechelics with carboxylate functional groups at both ends have been shown to assemble into hexagonal nanocrystal platelets with a height defined by their chain length in basic CsOH-solution. In this coarse grained (CG) simulation study we show how properties of the functional groups alter the aggregation and crystallization behavior of those telechelics.
Systematic variation of the parameters of the CG model showed that important factors which control nanoparticle stability and structure are the PE chain length and the hydrophilicity and the steric demand of the head groups.
To characterize the aggregation process we analyzed the number and size of the obtained aggregates as well as intramolecular order and intermolecular alignment of the polymer chains. By comparison of CG and atomistic simulation data, it could be shown that atomistic simulations representing different chemical systems can be emulated with specific, different CG parameter sets.
Thus, the results from the (generic) CG simulation models can be used to explain the effect of different head groups and different counterions on the aggregation of PE telechelics and the order of the obtained nanocrystals.
Modelling the visual response to an OUReP retinal prosthesis with photoelectric dye coupled to polyethylene film
Objective: Retinal prostheses have been developed to restore vision in blind patients suffering from diseases like retinitis pigmentosa.
Approach: A new type of retinal prosthesis called the Okayama University-type Retinal Prosthesis (OUReP) was developed by chemically coupling photoelectric dyes to a polyethylene film surface. The prosthesis works by passively generating an electric potential when stimulated by light. However, the neurophysiological mechanism of how OUReP stimulates the degenerated retina is unknown.
Main results: Here, we explore how the OUReP affects retinal tissues using a finite element model to solve for the potential inside the tissue and an active Hodgkin-Huxley model based on rat vision to predict the corresponding retinal bipolar response.
Significance: We show that the OUReP is likely capable of eliciting responses in retinal bipolar cells necessary to generate vision under most ambient conditions.
Chitosan-Functionalized Recycled Polyethylene Terephthalate Nanofibrous Membrane for Sustainable On-Demand Oil-Water Separation
The preservation of marine ecosystems is one of the most severe challenges at present. In particular, oil-water separation from oil spills and oily wastewater is important. For this reason, a low-cost, effective, and sustainable polymeric solution is in high demand. In this work, a controlled-wettability membrane for selective separation of oil-water mixtures and emulsions is developed. The nanofibrous membrane is prepared via a facile and cost-effective electrospinning technique using environmentally sustainable materials, such as recycled polyethylene terephthalate and chitosan.
The effect of different concentrations of chitosan on the morphology, chemical composition, mechanical properties, wettability, and separation performance of the membrane is evaluated. The membranes exhibited underoil superhydrophobic and underwater superoleophobic behavior, which is essential to perform the selective separation. In fact, the designed filter has competitive antifouling properties (oil intrusion pressure > 45 kPa) and showed high heavy- and light-oil/water separation efficiencies (>95%) both for emulsions and immiscible mixtures.
In vitro bio-interaction responses and hemocompatibility of Nano-based Linear Low-Density Polyethylene Polymer Embedded with Heterogeneous TiO 2/ZnO Nanocomposites for biomedical applications
An innovative nano-base polymer that scavenges radicals and reactive oxygen species exhibits potential antibacterial properties, which are crucial in the biomedical field, particularly in reducing nosocomial infections. However, the safety of this nano-based polymer, which has direct contact with the human system, has not been fully understood. The present study investigated the cytocompatibility and hemocompatibility responses of linear low-density polyethylene polymer (LLDPE) embedded with difference ratios of heterogeneous TiO2/ZnO nanocomposites.
Exposure of the blood and fibroblast cells to LLDPE/100Z and LLDPE/25T75Z/10% nanocomposite films for 48 and 72 h decreased their viability by less than 40%, compared with LLDPE, LLDPE/100T and LLDPE/25T75Z/5% nanocomposite films. It also presented possible cellular damage and cytotoxicity, which was supported by the findings from the significant release of extracellular lactate dehydrogenase (LDH) profiles and cell survival assay Further observation using an electron microscope revealed that LLDPE films with heterogeneous 25T75Z/5% promoted cell adhesion.
Moreover, no hemolysis was detected in all ratios of heterogeneous TiO2/ZnO nanocomposite in LLDPE film as it was less than 0.2%, suggesting that these materials were hemocompatible. This study on LLDPE film with heterogeneous TiO2/ZnO nanocomposites demonstrated favorable biocompatible properties that were significant for advanced biomedical polymer application in a hospital setting.
Synthesis of novel polymeric nanoparticles (methoxy-polyethylene glycol-chitosan/hyaluronic acid) containing 7-ethyl-10-hydroxycamptothecin for colon cancer therapy: in vitro, ex vivo and in vivo investigation
- The goal of the current study was to target 7-ethyl-10-hydroxycamptothecin (SN38) orally to colon tumours by synthesizing a targeting polymer. To achieve the optimum delivery for SN38, initially methoxy-polyethylene glycol (mPEG)-chitosan was synthesized and then nanoparticles were developed through ionic gelation between mPEG-chitosan and hyaluronic acid as a ligand for cell-surface glycoprotein CD44 receptor.
- The SN38 was loaded in nanoparticles (SN38-NPs) using the non-covalent physical adsorption method. The size of the optimized SN38-NPs was 226.7 nm, encapsulation efficiency was 89.23% and drug content was 7.98 ± 0.54% in the optimum formulation. The attachment of mPEG to chitosan was confirmed by proton nuclear magnetic resonance.
- The results of differential scanning calorimetry and Fourier transforms infra-red analysis indicated that SN38 existed in amorphous form and functional groups of SN38 protected in the formulations which could be a sign of suitable encapsulation of SN38 in SN38-NPs. In vitro study indicated that SN38-NPs were more potent against the cancer cells than free SN38.
- The cellular uptake of SN38-NPs improved up to 1.6-fold against human colorectal adenocarcinoma (Caco-2) cells. Moreover, SN38-NPs remarkably demonstrated superior anti-tumor efficacy in contrary to pure SN38. This suggests the advantage of SN38-NPs as a potent oral drug carrier which could be further explored for clinical investigations.
In-Plane Shear Strength of Single-Lap Co-Cured Joints of Self-Reinforced Polyethylene Composites
The present study introduces the analysis of single-lap co-cured joints of thermoplastic self-reinforced composites made with reprocessed low-density polyethylene (LDPE) and reinforced by ultra-high-molecular-weight polyethylene (UHMWPE) fibers, along with a micromechanical analysis of its constituents. A set of optimal processing conditions for manufacturing these joints by hot-press is proposed through a design of experiment using the response surface method to maximize their in-plane shear strength by carrying tensile tests on co-cured tapes.
Optimal processing conditions were found at 1 bar, 115 °C, and 300 s, yielding joints with 6.88 MPa of shear strength. The shear failure is generally preceded by multiple debonding-induced longitudinal cracks both inside and outside the joint due to accumulated transversal stress. This composite demonstrated to be an interesting structural material to be more widely applied in industry, possessing extremely elevated specific mechanical properties, progressive damage of co-cured joints (thus avoiding unannounced catastrophic failures) and ultimate recyclability.
